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Inventi Impact: Nutraceuticals

Articles

  • Inventi:pnc/175/13
    HYPOCALORIC DIET SUPPLEMENTED WITH PROBIOTIC CHEESE IMPROVES BODY MASS INDEX AND BLOOD PRESSURE INDICES OF OBESE HYPERTENSIVE PATIENTS â?? A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY
    30-Sep-2013 Research 2013 : October - December
    Khaider K Sharafedtinov, Oksana A Plotnikova, Ravilay I Alexeeva, Tatjana B Sentsova, Epp Songisepp,\r\nJelena Stsepetova, Imbi Smidt, Marika Mikelsaar

    Background: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500\r\nkcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche\r\nSammlung f�¼r Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic syndrome in Russian\r\nadults with obesity and hypertension.\r\nMethods: In this 3-week, randomized, double-blind, placebo-controlled, parallel pilot study, 25 subjects ingested\r\nprobiotic cheese and 15 ingested control cheese. Fifty grams of each cheese provided 175 kcal of energy. Blood\r\npressure (BP), anthropometric characteristics, markers of liver and kidney function, metabolic indices (plasma\r\nglucose, lipids, and cholesterol), and urine polyamines were measured. Counts of fecal lactobacilli and L. plantarum\r\nTENSIA were evaluated using molecular methods. The data were analyzed by t-test for independent samples and\r\nSpearmanâ��s partial correlation analysis.\r\nResults: The probiotic L. plantarum TENSIA was present in variable amounts (529.6 �± 232.5 gene copies) in 16/25\r\n(64%) study subjects. Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group\r\nversus the control cheese group. The changes in BMI were closely associated with the water content of the body\r\n(r = 0.570, p = 0.0007) when adjusted for sex and age. Higher values of intestinal lactobacilli after probiotic cheese\r\nconsumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475,\r\np = 0.006). In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in\r\nboth groups. A positive association was detected between TENSIA colonization and the extent of change of\r\nmorning diastolic BP (r = 0.617, p = 0.0248) and a trend toward lower values of morning systolic BP (r = -0.527,\r\np = 0.0640) at the end of the study after adjusting for BMI, age, and sex.\r\nConclusion: In a pilot study of obese hypertensive patients, a hypocaloric diet supplemented with a probiotic\r\ncheese helps to reduce BMI and arterial BP values, recognized symptoms of metabolic syndrome

    How to Cite this Article
    CC Compliant Citation: Sharafedtinov et al.: Hypocaloric diet\r\nsupplemented with probiotic cheese improves body mass index\r\nand blood pressure indices of obese hypertensive patients - a\r\nrandomized double-blind placebo-controlled pilot study.\r\nNutrition Journal 2013 12:138, doi:10.1186/1475-2891-12-138.
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